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Question about video series

When making a series, do you get a debuff anytime you use an actor that has been in the same video series before, or when you use the same combo of actors?
For example, I know this would give a debuff:
Actor A + Actor B, where both have starred in previous video together.
But how about Actor A + Actor C, where actor C is brand new to the series? Would this video have a debuff?

TLDR: In a video series, are any actor repeats bad, or only repeat combos of actors?